Non-compartmental pharmacokinetic parameters were assessed. Results: Armodafinil and modafinil both had a mean single-dose terminal elimination half-life of approximately 13 hours, with similar mean maximum plasma drug concentration C max and median time to C max values.
After reaching C max , plasma concentrations appeared to decline in a monophasic manner with armodafinil, but in a biphasic manner with modafinil due to the initial rapid elimination of its S-isomer. Conclusions: Despite similar half-lives, plasma concentrations following armodafinil administration are higher late in the day than those following modafinil administration on a milligram-to-milligram basis.
The different pharmacokinetic profile of armodafinil may result in improved wakefulness throughout the day in patients with ES compared with modafinil. In a meta-analysis comparing armodafinil and modafinil for obstructive sleep apnea, both drugs were found to be effective for treating sleepiness. Patients taking either drug tolerated side effects and experienced improved daytime wakefulness. Armodafinil has been shown to have higher plasma concentrations in the body later in the day.
Higher armodafinil levels in the body may result in better wakefulness compared to modafinil. While either drug can be used as a treatment for excessive sleepiness, it is best to consult a doctor for medical advice. Currently, there are no definitive studies that say one is more effective than the other.
Armodafinil is usually prescribed as a mg tablet taken once daily. It is widely available as a generic medication that is covered by Medicare and insurance plans.
This price can be brought down with a SingleCare discount card. Depending on your insurance plan, modafinil may be covered.
In fact, Medicare and most insurance plans cover modafinil for approved purposes. At participating pharmacies, you can use a SingleCare savings card to save money. The most common side effects associated with armodafinil and modafinil are headache, nausea, dizziness, and insomnia. Modafinil may be more likely to cause other side effects such as nervousness, nasal congestion rhinitis , diarrhea, and back pain.
Both medications can also cause dry mouth, indigestion dyspepsia , and anxiety. Side effects related to weight loss can also occur. Some people who take armodafinil or modafinil may experience decreased appetite.
Other rare but serious side effects include allergic reactions such as rash and shortness of breath. Psychiatric side effects such as depression or psychosis are also possible. Seek medical attention if you experience these side effects. This may not be a complete list. Consult your doctor or pharmacist for possible side effects.
Source: DailyMed armodafinil , DailyMed modafinil. Armodafinil and modafinil share many of the same drug interactions. In other words, they can affect how certain drugs are processed in the body. Armodafinil and modafinil may reduce the effectiveness of steroidal contraceptives. Alternative methods of contraception are recommended during treatment with armodafinil or modafinil and for one month after discontinuation of these drugs. Armodafinil and modafinil may increase the clearance of cyclosporine from the body.
If taken together, the effectiveness of cyclosporine may be reduced. On the other hand, armodafinil and modafinil may increase the levels of other drugs known as CYP2C19 substrates. Increased drug levels may lead to adverse effects. This may not be a complete list of all possible drug interactions. Consult a doctor with all the medications you may be taking. Both armodafinil and modafinil can cause serious rash. These drugs should be discontinued immediately in cases of severe rash.
Do not take these drugs if you have a suspected allergy to any of their active ingredients. Doses of armodafinil or modafinil may need to be adjusted in order to improve sleepiness during the day. While optimizing doses, persistent sleepiness can still occur.
Armodafinil and modafinil may cause psychiatric symptoms especially in those with a history of psychosis , depression, or mania. These medications should be monitored or even discontinued in severe cases of psychiatric effects.
Stimulant-like drugs may cause adverse effects in the heart and cardiovascular system. Those with high blood pressure may need to be monitored when first starting armodafinil or modafinil. Consult a doctor if you experience chest pain, shortness of breath, or palpitations rapid heartbeat. Armodafinil is also known by its brand name Nuvigil. Armodafinil is used to treat excessive sleepiness from narcolepsy and other sleep disorders.
It comes in 50 mg, mg, mg, and mg tablets. Modafinil is the generic name for Provigil. Modafinil is FDA-approved to treat daytime sleepiness that results from sleep disorders. It can treat obstructive sleep apnea, narcolepsy , and shift work disorder. Armodafinil and modafinil contain similar ingredients but they are not the same. Armodafinil contains the R-enantiomer of modafinil.
Modafinil contains a racemic mixture of R- and S-modafinil. Armodafinil and modafinil are similar in effectiveness and safety. However, armodafinil may have higher levels in the body over the course of the day. The effects of armodafinil may last longer compared to modafinil.
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