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When Ras is mutated, it encodes for a protein that causes an uncontrolled growth-promoting signal. Most cases of pancreatic cancer have a point mutation in the Ras gene. Many cases of lung, colon, and thyroid tumors have also been found to have a mutation in Ras.

Another well-known proto-oncogene is HER2. This gene makes protein receptors that are involved in the growth and division of cells in the breast. Many people with breast cancer have a gene amplification mutation in their HER2 gene.

This type of breast cancer is often referred to as HER2- positive breast cancer. It occurs when a chromosomal translocation moves a gene enhancer sequence near the Myc proto-oncogene.

Cyclin D is another proto-oncogene. Its normal job is to make a protein called Rb tumor suppressor protein inactive. In some cancers, like tumors of the parathyroid gland, Cyclin D is activated due to a mutation.

As a result, it can no longer do its job of making the tumor suppressor protein inactive. This in turn causes uncontrolled cell growth. Your cells contain many important genes that regulate cell growth and division. The normal forms of these genes are called proto-oncogenes.

The mutated forms are called oncogenes. Oncogenes can lead to cancer. You may be able to lower your risk of cancer-causing mutations by:. Even with a healthy lifestyle, changes can still happen in a proto-oncogene. This is why researchers are currently looking into oncogenes as a major target for anticancer drugs. Two of the main types of genes that play a role in cancer are oncogenes and tumor suppressor genes.

Proto-oncogenes are genes that normally help cells grow. When a proto-oncogene mutates changes or there are too many copies of it, it becomes a "bad" gene that can become permanently turned on or activated when it is not supposed to be. When this happens, the cell grows out of control, which can lead to cancer. This bad gene is called an oncogene. It may be helpful to think of a cell as a car. For it to work properly, there need to be ways to control how fast it goes.

A proto-oncogene normally functions in a way that is much like a gas pedal. It helps the cell grow and divide. An oncogene could be compared with a gas pedal that is stuck down, which causes the cell to divide out of control.

Birth Defects: Prevention and Treatment. Copy Number Variation and Genetic Disease. Genetic Causes of Adult-Onset Disorders. Somatic Mosaicism and Chromosomal Disorders. Trisomy 21 Causes Down Syndrome. Genetic Origins of Microbial Virulence. Genetics of the Influenza Virus.

Pathogenicity: Microbial Virulence. Complex Diseases: Research and Applications. Gene Interaction and Disease. Gene Mapping and Disease. Multifactorial Inheritance and Genetic Disease. Polygenic Inheritance and Gene Mapping. Genomic Imprinting and Patterns of Disease Inheritance. Chromosome Abnormalities and Cancer Cytogenetics. Genes, Smoking, and Lung Cancer. Genetic Regulation of Cancer. Gleevec: the Breakthrough in Cancer Treatment. Human Chromosome Translocations and Cancer.

Proto-oncogenes to Oncogenes to Cancer. Cytogenetic Methods in Diagnosing Genetic Disorders. Gene-Based Therapeutic Approaches. Personalized Medicine: Hope or Hype? Citation: Chial, H. Nature Education 1 1 What drives cancer cells to grow and divide uncontrollably turning into cancer? Studies of proto-oncogenes reveal some clues about how normal cellular processes mutate and go awry. Aa Aa Aa. Figure 1. Introduction to Proto-oncogenes.

Underlying genetic mechanisms associated with oncogene activation include the following: Point mutations, deletions, or insertions that lead to a hyperactive gene product Point mutations, deletions, or insertions in the promoter region of a proto-oncogene that lead to increased transcription Gene amplification events leading to extra chromosomal copies of a proto-oncogene Chromosomal translocation events that relocate a proto-oncogene to a new chromosomal site that leads to higher expression Chromosomal translocations that lead to a fusion between a proto-oncogene and a second gene, which produces a fusion protein with oncogenic activity.

Examples of Oncogenes. Figure 2. Targeting Oncogene Addiction to Treat Cancer. References and Recommended Reading Adamson, E. Development 99 , — American Cancer Society. Cancer Cell 1 , 31—36 Ellerman, C. Zentralblatt fur Bakteriologie 46 , — Heisterkamp, N. Science , Rous, P. Journal of Experimental Medicine 12 , — ———. Journal of Experimental Medicine 13 , Thomas, R. Nature Genetics 39 , — link to article Weinstein, I. Article History Close. Share Cancel.

Revoke Cancel. Keywords Keywords for this Article. Save Cancel. Flag Inappropriate The Content is: Objectionable. When a germline mutation is inherited, it is present in all body cells from birth. Mutations that you are not born with, but that happen by chance over time, are said to be acquired. Acquired mutations are not present in all cells of the body, are not inherited, and are not passed down to your children.

Most human cancers are thought to be caused by acquired somatic mutations. Germline mutations are involved in a small portion of cases.

Tumors form when cell growth gets out of control. In the human genome, many types of genes control cell growth in a very precise way. When these genes have an error in their DNA code, they may not work properly.

They are said to be altered or mutated. In most cases of cancer, many mutations must happen one after another in different genes in a specific group of cells over time to cause malignancy.

The different types of mutated genes that can lead to cancer are described below. Remember, it usually takes mutations in several of these genes for a person to develop cancer. What specifically causes mutations to happen one after another in these genes is largely unknown.

Mutations can be caused by things in the environment known to increase the risk for cancer carcinogens. The development of mutations is also a natural part of aging. These are altered forms of genes known as proto-oncogenes.






















The most straightforward mechanism of a manual pencil sharpener is the blade , which acts as a wedge due to its angle and the screw that holds it attached to the outer cover. The pencil is placed inside a small hole and rotates in a circular motion on each turn, shaving the wood and making the tip less thick. A crank sharpener incorporates a lever, which is the one that turns the blades inside.

In an electric pencil sharpener, the machinery includes an oscillation motor, which contains a system of pulleys of rods and chains, two gears and a cam that generates the movement of the motor.

A cam is a small wheel mounted on an axle that makes the oscillating motion of the engine. The rod and chain pulley system carries the electric current to the motor gears. The small speeds of the motor transfer the electrical energy to the blade, causing it to spin rapidly and sharpen the pencil placed inside. The best electric pencil sharpeners , using its engine, imitates the action of a manual pencil sharpener. The electric pencil sharpeners have blades that guarantee the quality of the tip of your pencils after each use.

Durable metal blades guarantee sound advice every time. These are found in electric pencil sharpeners, and although they are durable, they do not resist the same user that you would expect from a commercial quality sharpener. The blades on most models lose their edge with use and eventually need to be replaced.

The depositor container that serves to catch the shavings of a pencil is usually made of plastic and has a magnet or other type of lock in the mechanism to keep it in place. The machine itself would align the knife and sharpen it within minutes, if not seconds! This method is much quicker and simpler, but it requires an electrical connection and a certain amount of care. The maintenance of the machine, such as emptying the shavings bin, is also necessary.

There are several options for both kinds of sharpeners in terms of price, quality, and size. However, we must make a decision to use at least one of these. Cutting with dull knives is definitely not a good idea. Or at least check out the Trizor XV Review. Both kinds of knife sharpeners have their pros and cons. However, if we have to choose just one, we should look at what our needs are. We should also consider our personal preferences. Below are some general factors we should consider when deciding between the two kinds of sharpeners.

This is not true, knife experts can prove you wrong. The quality of the knife does make a difference. Apart from serrated and straight blades, there is also a difference between American and Asian blades.

Conventional European and American knives have degree angle and Japanese style knives have degree. The kind you have would determine which knife sharpener you want to purchase. If you fancy ceramic knives, do not use a steel blade knife sharpener. Cherish your ceramic knives and get good quality Sharpeners for Ceramic Knives.

Manual knife sharpeners are usually cheaper than electric ones. However, the prices may be just as high as electric sharpeners if you go for a very high-end brand. Usually, you can get a decent manual knife sharpener for ten or twenty dollars.

On the other hand, electric knife sharpeners could cost you quite a bundle. If you go for a cheap option, it may need a lot of repairs and would probably not last as long as a manual one of the same price.

Many modern small families are now living in apartments instead of big houses. As a result, the kitchens are also getting smaller each day. Most of us simply cannot afford to have large appliances taking over the precious counter space.






















E-CRM, or Electronic Customer Relationship Management, is an integrated online sales, marketing and service strategy that is used to identify, attract and retain an organisation's customers.

By providing the means to manage and coordinate customer interactions, CRM helps companies maximise the value of every customer interaction and in turn improve corporate performance. It describes improved and increased communication between an organisation and its clients by creating and enhancing customer interaction through innovative technology.

E-CRM software provides profiles and histories of each interaction the organisation has with its customers, making it an important tool for all small and medium businesses. E-CRM also allows extensive configuration of roles, so that you can ensure selected members have access only to the information they need.

Customer Management: Provides access to all customer information including enquiry status and Correspondence. Knowledge Management: A centralised knowledge base that handles and shares customer Information. Account Management: Access to customer information and history, allowing sales teams and customer service teams to function efficiently. Case Management: Captures enquiries, escalates priority cases and notifies management of unresolved issues.

Back-end integration: Blends with other systems such as billing, inventory and logistics through relevant customer contact points such as websites and call centres. Basically, this tool is the 4. E-CRM application is becoming important for all companies in all fields. An effective ECRM will help improve interaction with customers.

If you are familiar with the concept of CRM, you will know that this term hides a double meaning:. CRM interacts with customers via phone, distribution channels, or fax. On the other hand, E-CRM contacts customers through the Internet, e-mail, and the latest technologies.

ECRM has evolved over time. The first computer systems storing customer information date from the mids, but only in the late 90s, the CRM software market started to develop. Therefore, CRM existence is only 20 years old. On the contrary, the history of CRM stretches back thousands of years. CRM was born with commerce. Traders and businesses have always cared about Customer Relations because the human factor is always crucial in trading.

It was in the s that computing took off. Microcomputers or PCs, personal computers are beginning to appear in organisations. Client-server architectures, which made it possible to create networked computer systems, emerged around the middle of the decade. This technological revolution gave birth to the first computerized databases.

This technology was then used, for the most part, by businesses or salespeople in their door-to-door sales and marketing activities. They simplify access to customer information. The term Customer Relationship Management originated in the mids. There is a fight over its fatherhood. Their functionalities helped to rationalize and simplify certain tasks of the sales forces at the prospecting stage in B2B.

Besides, we can also notice the first Contact Center management system that manages the after-sales process. At the same time, more and more organizations are realizing that CRM not only serves to reduce costs but can help increase business revenue by making possible a richer Customer Relationship and better understanding customer needs.

In the early s, we began to talk about eCRM to qualify CRM system integrating the management of web contact points. It was in the mids that a new category of tools blew up: Marketing Automation , intended to automate a part of the marketing task. In , the HubSpot platform was launched, which creates automated relationship scenarios and sets up inbound marketing strategies.

Another major development: the end of the s saw the emergence of social media and the rise of Social CRM. From , major media groups used Twitter to interact directly with their customers. The beginning of the s was first marked by the development of the SaaS model , which was accompanied by a new economic model, based on subscription. The CRM system has accelerated in recent years and has continued to grow steadily.

The impact of COVID has switched all ECRM into virtual sessions by using the latest communications technologies to facilitate the meetings between collaborators like buyers and suppliers.

Here are some factors that we should consider in order to implement ECRM effectively:. Customer relationship management. ECRM Meaning, a useful tool for your electronic customer relationship management.

Electronic customer relationship management E-CRM is the application of Internet-based technologies such as emails, websites, chat rooms, forums and other channels to achieve CRM objectives. It is a well-structured and coordinated process of CRM that automates the processes in marketing, sales and customer service. Electronic customer relationship management provides an avenue for interactions between a business, its customers and its employees through Web-based technologies.

Electronic customer relationship management is motivated by easy Internet access through various platforms and devices such as laptops, mobile devices, desktop PCs and TV sets.

It is not software, however, but rather the utilization of Web-based technologies to interact, understand and ensure customer satisfaction. A typical E-CRM strategy involves collecting customer information, transaction history and product information, click stream and contents information. It then analyzes the customer characteristics to give a transactional analysis consisting of the customer's profile and transactional history, and an activity analysis consisting of exploratory activities showing the customer's navigation, shopping cart, shopping pattern and more.

Businesses that strategize and implement an E-CRM solution are able to align their processes around technology to effectively deliver seamless, high-quality customer experience across all channels. Customers have the power to help themselves through online personalized services that are made available on demand. The Internet provides a simple and ideal medium where customers can get information from websites, buy products and find answers using FAQ sections, forums or chat rooms.






















A cake in her vicinity is sure to disappear in a record time of 10 seconds. Most likely to find her soulmate on a food app. Listen to the latest songs , only on JioSaavn. Story Progress Back to home. Here's how chia seeds and lemon may help managing the condition. Chia seed-infused in water is perhaps the best way to reap in the benefits this superfood. Highlights Hypertension is one of the major concerns in the world of health today.

About Aanchal Mathur Aanchal doesn't share food. Chia seeds are said to be exceptionally high in omega-3 fatty acids, which have been shown to work as a blood thinner and may reduce blood pressure. Leading health experts advise soaking chia seeds in water for half an hour and then consuming the water.

This process can be repeated daily for a month for effective blood pressure lowering effects. Chia seeds are relatively easy to find in any major grocery store said Medical News Today.

Along with consuming chia infused water, cutting down on the amount of salt used will also have a great effect on your blood pressure reading. High blood pressure: Lifestyle changes to reduce reading. All Bombay Times print stories are available on. We serve personalized stories based on the selected city OK. Go to TOI. The Times of India. Never say these things to a Virgo. Weekly career horoscope: 15th to 21st November, Relationship tips to take from Rajkummar Rao, Patralekhaa's love story.

Why do happy people cheat? World Kindness Day: 5 acts of kindness to adopt when dating online. Lifelong vows a couple should make. Indian designer finds sustainable way to high fashion. Rajkummar Rao and Patralekhaa have a stylish white themed engagement party.

Amid wedding rumours, Vicky Kaushal's dulhania Katrina Kaif sets lehenga goals. Samantha Ruth Prabhu's revenge dressing game is on point. Chile's desert dumping ground for fast fashion leftovers.

Children's Day: Signs that your child needs remedial therapy. Healthy diet to keep your children safe from the risk of diabetes. Celeb dads who prove that divorce isn't the end of parenting duties.

The impact of the rise in parental age on kids and parents. Tips to make your kids more assertive. Bollywood divas prove you can't go wrong with nude lipsticks. Kangana Ranaut uses Chuli oil for beautiful hair. What's new in the beauty industry? Perfect manscaping tips for millennial men. When Shruti Haasan openly admitted to undergoing plastic surgery. However, this fact is true of most seeds. In most cases, people should soak chia seeds in water before consuming them or drink water while eating them to aid proper digestion.

Ground chia seeds are also a suitable alternative to whole seeds — the body is able to absorb the full nutritional benefits of chia seeds better. People can also opt for sprouted chia seeds. Allowing chia seeds to germinate optimizes the availability of proteins and increases their calcium content.

Many studies have shown that chia seeds contain vital micronutrient and macronutrient components. The most common macronutrients are carbohydrates, proteins, dietary fiber, and fats. Chia seeds have high percentages of omega-3 and omega-6 acids. As the body cannot naturally create these nutrients, everyone must consume these essential dietary components. Some of the health advantages of chia seeds include improved blood sugar and lower blood pressure.

However, people should note that animal studies do not necessarily apply to humans. More research must continue in this area to better understand the potential effects of chia seeds. Learn more about the health benefits of chia seeds. Some alternatives to chia seeds include high fiber foods such as vegetables, legumes, nuts, fruits, and grains. For people interested in boosting their fatty acid consumption, fish is a suitable alternate source of omega-3 fatty acids.

Flaxseed, in particular, contains many of the same benefits as chia seeds, but it is also difficult to digest unless milled. In addition, flaxseed contains lignans, a natural chemical compound. According to the American Heart Association , lignans may potentially protect against prostate cancer and reduce tumor growth in breast cancer.






















Once the metal is cut, it can be shaped to any form. With the snap-through, shear occurs when piercing metal. There are both mechanically and hydraulically driven presses. Mechanical presses typically use an eccentric drive, while hydraulic presses use hydraulic cylinders to move the ram up and down.

Mechanical presses are powered by a motor, which runs the flywheel. The flywheel stores kinetic energy to turn the wheel down towards the plate.

These types of presses can operate at a steady pace and can easily produce metal products in assembly-style environments. Mechanical presses can also reach higher cycles per unit of time and are commonly used in industrial press shops. With a hydraulic press, there is constant press force during the stroke and with a mechanical press, there is a press-force progression.

Swaging Rounded Metal. This is similar to flattening in that it makes a work piece thinner, but this process is usually used for wires instead of sheet metal. Swaging wires makes one end narrower so it can fit into an opening more easily. Piercing Metal. Instead of simply flattening the metal, the tool and die from a sheet metal stamping machine can puncture all the way through a piece of metal.

This creates openings that can be used to connect multiple work pieces. Coining Metal. Rather than punch a small hole in a piece of metal, the tool and die of the sheet metal stamping machine can be used to press the sheet metal into a specific shape such as a coin.

It is also a faster process with a limited amount of wasted scrap. Transfer die stamping is similar to progressive die stamping, but the part is separated from the metal trip early on in the process and is transferred from one stamping station to the next by another mechanical transport system, such as a conveyor belt.

This process is usually used on larger parts that may need to be transferred to different presses. Four-slide stamping is also called multi-slide or four-way stamping. This technique is best-suited for crafting complex components that have numerous bends or twists.

It uses four sliding tools, instead of one vertical slide, to shape the workpiece through multiple deformations. Two slides, or rams, strike the workpiece horizontally to shape it, and no dies are used. Multi-slide stamping can also have more than four moving slides. Four-slide stamping is a very versatile type of stamping, as different tools can be attached to each slide.

It also has a relatively low cost, and production is fast. Fine blanking , also known as fine-edge blanking, is valuable for providing high accuracy and smooth edges.

Usually done on a hydraulic or mechanical press, or by a combination of the two, fine blanking operations consist of three distinct movements:. Fine blanking presses operate at higher pressures than those used in conventional stamping operations, hence tools and machinery need to be designed with these higher operating pressures in mind. The edges that are produced from fine blanking avoid fractures as produced with conventional tooling and surface flatness can exceed that available from other stamping methods.

Since it is a cold extrusion technique, fine blanking is a single-step process, reducing the overall costs of fabrication. The three common types of stamping presses include mechanical, hydraulic, and mechanical servo technologies.

Usually, presses are linked to an automatic feeder that sends sheet metal through the press either in coil or blank form. Mechanical presses use a motor connected to a mechanical flywheel to transfer and store energy. Their punches can range in size from 5mm to mm, depending on the particular press. Mechanical pressing speed also varies, usually falling between the range of twenty and 1, strokes per minute, but they tend to be faster than hydraulic presses. These presses can be found in an array of sizes that stretch from twenty to 6, tons.

They are well-suited for creating shallower and simpler parts from coils of sheet metal. Hydraulic presses use pressurized hydraulic fluid to apply force to the material. Hydraulic pistons displace fluid with a force level proportional to the diameter of the piston head, allowing for an advanced degree of control over the amount of pressure, and a more consistent pressure than a mechanical press.

Additionally, they feature adjustable stroke and speed capabilities, and can typically deliver full power during any point in the stroke. These presses usually vary in size from twenty to 10, tons and offer stroke sizes from about 10mm to mm.

Hydraulic presses are usually used for smaller production runs to create more complicated and deeper stampings than mechanical presses. They allow for more flexibility because of the adjustable stroke length and controlled pressure. Mechanical servo presses use high capacity motors instead of flywheels. They are used to create more complicated stampings at a faster speed than hydraulic presses. The stroke, slide position and motion, and the speed are controlled and programmable.

They are powered by either a link-assisted drive system or a direct drive system. These presses are the most expensive of the three types discussed. How does metal stamping work exactly? Although it sounds complex, metal stamping is a relatively simple manufacturing process. It requires the use of a stamping press to deform and shape a metal workpiece.

Stamping presses are heavy-duty machines that essentially sandwich a metal workpiece between a set of dies. They typically have one die on top and another die on the bottom. During use, the stamping press will push the top die down onto the bottom die.

Since the metal workpiece is placed between these two dies, it will take their respective shape. The bottom of the metal workpiece will take the shape of the bottom die.

The top of the metal workpiece, on the other hand, will take the shape of the top die. Although there are several types of stamping presses, most of them consist of a few basic parts.

They have a bolster plate, for instance.






















In discussing Duns Scotus, I have given less from his writings than has been my wont with other philosophers. Later on, I believe, a child is wont to have his favourite colour, and to be ready to defend it against the preferences of others. He had been wont to do this on other occasions, because the enemy with nine ships was within sight of the fort. In cases in which no attempt is made to ignore the accusation, the small wits are wont to be busy discovering exculpations.

Yet the feeling is in most children weak and vacillating, and is wont to be mixed with other and less noble ones. New Word List Word List. Save This Word! See synonyms for wont on Thesaurus. See antonyms for wont on Thesaurus. Most contractions in English are pretty straightforward: they are, they're; he would, he'd; is not, isn't; we will, we'll.

The two words join together, minus a few sounds. Put it together, and shorten it up. What could be easier? But that isn't the case for "will not," which becomes "won't" instead of "willn't. Why does the "will" change to "wo"? It doesn't really. Which is to say, we don't change it, our linguistic ancestors did.

We just inherited it from them as a unit.






















Omarion discography - American singer Omarion has released six studio albums, three collaborative albums, two extended plays EPs , one mixtape and thirty singles including eleven as a featured artist. Examples of in a sentence 4-star WR Omari Kelly makes commitment.

Marcelle Schuster. Five-star edge defender Omari Abor announces his top schools. River Greenholt. Gail Zboncak. Jettie Osinski. Damian Zemlak. Add a sentence Cancel. Ahmad Sokarno. View article al. Omari Kelly becomes Auburn football's second 4-star commitment in one day Kelly was the second recruit to pledge with Auburn football Thursday, joining two-sport athlete Tre Donaldson.

Synonyms for omari Add synonyms. Antonyms for omari Add antonyms. Comments about omari. The correct way to pronounce erudite is? Pronunciation poll Vote. Ask your friends X. French words -Gloria Mary. English -Gloria Mary. Italian -Gloria Mary. Popular food and drinks -Gloria Mary. Afrikaans -Gloria Mary.

You can listen this name Omari audio pronunciation and search your name to learn how to speak it in Portuguese. Brazilian Portuguese is most often pronounced exactly as it is spelled. So hear the name Omari carefully and speak to us in case of issues. Russian name pronunciation guide for the name Omari.

More over learn correct Russian language pronunciation and get authentic Russian accent of name Omari. You may wonder how to spell name Omari in Spanish.

Translation to Spanish, pronunciation with a qulaity audio file. Translate name Omari in Spanish online and download now our free audio file to use any time at no charge.

In English is would be Meshico. An audio pronunciation of name Omari in Spanish Mexico. How to pronounce Swedish names. A guide for English speakers to Swedish and Norwegian pronunciation for the name Omari. Learn how to pronounce common names for girls in Sweden. See the most awesome name, which people are searching name during last 24 hours. What does Omari mean? Short Url: Copy.

Your Email: Send Favorit Names. Home Boys Girls BornToday Most Popular. Short Names. Modern Names. It is classified in the register of the feelings with an idealistic and dynamic operation. Letter I meaning for the name Omari It belongs to the affective and emotional letters while being classified in the register of feelings, working dynamically with an idealistic background.

Sensitive feelings of it often cast lightning strikes such as a lightning rod. Search For Name Pronunciations. Most names exist in many different languages and can have different pronunciations depending on said language. We try to teach you the correct way on how to pronounce the name Omari in English.

This means that you need to know the 26 letter English alphabet and how to phonetically say them. Once you know how a single letter should sound, pronouncing a full name becomes much easier.

When saying a name it is important to find where the emphasis is located. Some letters might be silent while others can be very loud.






















A pop rivet is then inserted through the drilled hole and the rivet body is brought into contact with the parts. A pop rivet gun is placed on the rivet, pulling the mandrel into the rivet body, causing it to expand and grip the parts to be joined. Once gripped, the mandrel snaps, permanently holding the rivet in place. This results in a localised joint. They are used to make high strength joints in a range of materials, including metals, plastics, wood and leather. Typically, the processes is used for joining plastic or sheet metal.

To enable pop rivets to meet the requirements of a wide variety of applications, they are available in many materials, including:. Large, industrial air rivet guns used on structured steel often require two hands and a steady user, but smaller guns resemble tools such as a power drill and ergonomically mimic that are simply load, point, and shoot.

Air rivet guns offer innumerable advantages over manual riveters and depending on the application are preferable to cordless, battery-powered rivet guns. Some of the pros of pneumatic riveters include:. Air rivet guns are common in the aerospace and automotive industries, in which the assembly line and tight spaces of the product under construction require a fast, convenient, yet powerful riveting solution.

They also are often used in construction and metal fabrication. However, even the home handyman can benefit from the simplicity and efficiency of a pneumatic tool.

Plenty of practical household needs benefit from an air rivet gun, and with some projects, rivets add a nice aesthetic effect. And all of this can be achieved without putting too much stress on your hands. Looking for something specific? Air Time Pneumatic rivet guns also known has pneumatic hammers operate according to a simple concept: Compressed air propels the rivet into place when the user presses the trigger. Pros of Air Rivet Guns Air rivet guns offer innumerable advantages over manual riveters and depending on the application are preferable to cordless, battery-powered rivet guns.

Ease of use: Pneumatic guns follow a simple process to attach rivets. This allows users to place multiple rivets in a short span of time, without placing the physical stress on their hands that a manual riveting tool would. How to Use a Pop Rivet Gun No matter what type of pop rivet tool you choose, they are all designed to operate in basically the same way: First, determine that you have the right rivet for the job. You want to choose based on the size of the pre-drilled hole, the grip range, the joint thickness and desired strength, your materials, and other factors.

Next, you align the materials to be joined as desired and drill the hole for the rivet. You then load the pop rivet into the rivet gun mandrel first, so the sleeve is pointing outward.

Insert the body of the pop rivet all the way into the pre-drilled hole. The flange of the rivet should be flush to the joint. Squeeze the trigger of the power rivet gun or apply pressure to the levers on the manual rivet gun until you hear the snap sound that indicates the mandrel has been removed. Once the mandrel is snapped off, the collar becomes the rivet head. Lastly, the mandrel is collected. You will have to collect the mandrel yourself if you are using a manual rivet tool.

Most power rivet guns have a built-in receptacle to capture the mandrel once it is removed. Subscribe to our Weekly Digest Sign up to have the latest industry tips, tricks, and promotions delivered right to your inbox. Subscribe For Weekly Blog Updates. Popular Posts.






















South Florida at No. Dallas Baptist vs. Virginia in Columbia, S. LSU at No. After the conclusion of the super regionals on June 14, teams will have a few days before heading to the College World Series quarterfinals on June 19 where they will play in double-elimination brackets.

Super regionals will be hosted by either the higher seed or set on a neutral site. California would go undefeated through the inaugural CWS and beat Yale to capture the first title. The tournament has grown a lot since There are currently 64 teams that compete in four rounds two double-elimination brackets, two best-of-three series for the title. Since , the NCAA Division I baseball tournament field has been split into two qualifying groups: The automatic berths, and the at-large selections.

Since , that split sees 31 conference champions receive automatic berths, and 33 teams receive at-large bids, decided by the NCAA Division I Baseball Committee.

As part of that selection process, 16 teams receive national seeds, and are offered the option of hosting a super regional if they advance to the second round. The first round sees the 64 teams split into 16 brackets.

Each is a double-elimination bracket with four teams, seeded They knocked off the No. Originally to win the trophy in Omaha, they are down to after opening weekend. Gambling problem? Eligibility restrictions apply. The winners of the super regionals -- eight teams in all -- advance to the College World Series in Omaha. The College World Series is a double-elimination format until the final two teams are left standing. At that point, slates are wiped clean, and it's a best-of-three series to determine the national champion.

The field of 64 also includes eight national seeds, which you may consider the pre-tourney favorites to reach Omaha. Here they are for this year, ranked in order with their regular-season record: Arkansas, Texas, Tennessee, Vanderbilt, Arizona, TCU, Mississippi State, Texas Tech, If a national seed wins its region, then it hosts the super regional when possible.

Austin Regional 1 Texas vs. Central Connecticut State 2 Gonzaga vs. MLB rumors: Fast free agent frenzy coming? MLB free agent tracker: Market officially opens R. Watch Now:. How secure is Manfred's job as lockout looms? Dayn Perry 7 min read.






















The musicians were asked to invent new functions for common household objects. On average, they came up with 14 more uses than nonmusicians could. In a second experiment musicians dreamed up new uses for everyday items while the prefrontal lobes in their brains got scanned. And musicians had more activity in both sides of their frontal lobes than nonmusicians did. Researchers think these findings fit with musical talent—for example, pianists use each hand simultaneously to play different melodies and rhythms.

And they read notes, a left-hemisphere task, and immediately turn them into music, a right-hemisphere job. When it comes to creativity, harmonious hemispheres make beautiful music together. Already a subscriber?

When musicians practice, you may just think they are enhancing their musical skills. They are, however, enhancing every other skill they have. Being a musician isn't just about playing music, but learning to play everything else. Structured practice in music strengthens brain functions, particularly those of the visual, auditory and motor cortices. Musicians can use those strengthened brain functions and apply them to other activities. According to Collins, "playing music is the brain's equivalent of a full body workout.

It's not just remembering notes and finger placement, it's remembering everything else. According to Collins, musicians exhibit enhanced memory functions.

Because they use both sides of their brain, they are able to give their memories multiple tags, such as conceptual, emotional and audio tags, making it easier to extrapolate the memories when needed. Thus, musicians can create, store and retrieve memories more quickly and efficiently than the average person. As we all know, memories are important in our education.

We must remember our lessons, mistakes and those moments that can translate from one experience to the next in order to learn and grow. There is such a thing as mental maintenance.

We eat certain foods, take certain vitamins and exercise certain parts of our brain for longevity and health. Musicians, however, are conducting the best maintenance of all. According to a study published in the American Psychological Association, the number of years people spend playing instruments directly correlates to how strong their brains remain in later years. Due to changes in the brain organization that occurs when one learns music, those who spent years playing it help preserve cognitive functioning in advanced age.

The study, conducted on 70 older adults ages varying in musical activity, completed a comprehensive neuropsychological test. But newly published research suggests a low-tech way of retaining our mental agility: Learn to play a musical instrument. According to this research, people who spend many hours in the practice room not only process information unusually efficiently, but they also do a superior job of not letting occasional errors derail them.

These findings "suggest that playing a musical instrument might improve the ability to monitor our behavior and adjust our responses effectively when needed," writes a research team led by cognitive neuroscientist Ines Jentzsch of the University of St. In the journal Neuropsychologica, the researchers describe an experiment featuring 36 young adults. They were divided into four groups: Musicians who had accumulated at least 5, hours of practice; those who had clocked 2, to 5, hours; the lightweights or newcomers to music who had practiced for to 2, hours; and non-musicians.

As they performed these tricky tasks, their brains were continuously monitored via EEG recording. The results: People with more musical training responded faster than those with little or no training, with no loss in accuracy.






















New insights are not produced by formal manipulation, they depend on ideas and original ideas cannot be manufactured to order. If there is one over-riding theme common to all three books under review it is this view of mathematics as a creative enterprise, akin to creation in the arts.

Mathematics is a human activity and it has to be understood in that light. It has strict rules, but so do painting, music and poetry. Its soul does not lie in the rules but outside them. Moreover, on occasion, rules have to be broken or at least re-interpreted. In fact the greatest steps forward, either in mathematics or in the arts, occur when genius inspires a break of the rules.

Of all the arts, perhaps architecture is the one that most closely resembles mathematics. Strict engineering principles prevent a building falling down, there is geometry in its design, intricate detail in the finish but it is the overall architectural vision that is paramount. Oddly enough, mathematicians tend to compare themselves to poets who are superficially the least mathematical.

While the three books have much in common and agree on its poetic aspect, they cover different approaches to the subject. Very roughly and with overlaps they deal with the following three topics:. David Ruelle is a mathematical physicist who tries to explain to the general reader what mathematics is and how mathematicians go about their work.

Any mathematician reading it will recognize his description of our enterprise, both the formal day to day aspect and the more fundamental and creative process that gives the subject its life. The book is well organized, clearly written and gives a fair impression of the working mathematician. William Byers has written much more discursively and covers a lot more ground.

He is also more ambitious in that he wants to identify the essence of mathematical creativity, what makes it tick. Because he is writing a large book Byers can afford to spend much time on the history of mathematics and the major problems that it has faced on the way. He enjoys pointing out, with many examples, that contradiction and paradox have played a vital part in a subject where logic is supposed to be supreme. In fact contradictions are like the no-entry sign that faces the motorist who is making an incorrect turn, while a paradox is like one of those junctions where all roads have no-entry signs.

The highway engineer clearly has something to learn from such junctions and perhaps comes up with a new solution such as an underpass or flyover. Moreover the lessons it learns in the process may play a fundamental part in its future.

In a subject where clarity and precision are given the highest priority he is attracted to the situations where such clarity breaks down, where things are ambiguous. Rather than this being a weakness, a failure of the system, Byers sees such ambiguity as the catalyst for the creative process.

As long as several different outcomes are possible there is flexibility and openness. Studying ambiguities carefully can show hidden meanings, and open the door to new adventures. In all this Byers is quite persuasive and makes a good case, but I am not totally convinced. Trying to put one's finger on the nature of the creative process is over ambitious and doomed to failure. Byers gives many examples to support his view but he stretches the meaning of ambiguity to suit his purpose.

Though God may, in the Big Bang, have created the universe from a vacuum, human creation has antecedents. Almost by definition this pre-creation stage has to be incomplete, or ambiguous. What is created cannot have been clear in advance. But this use of ambiguity to explain creativity is almost a tautology. The key breakthrough would appear to pop up spontaneously after a dormant period where the conscious brain had signed off.

The book by Fitzgerald and James represents a collaboration between a psychologist and a mathematician. What interests them is the personality of the mathematician and how this is related to his work. Do mathematicians have certain personality traits in common? If so, does the mathematics produce the personality—too much work makes Jack a dull boy—or are those with such personalities just automatically attracted to mathematics?

Certainly, in the public eye, mathematicians must be prime candidates for the caricature of the absent-minded professor, who cannot remember if he has had lunch.

Fitzgerald and James both start with an interest in autism and specifically in that form of autism that is known as Asperger's Syndrome. This is characterized by a withdrawal from the external world, often accompanied by an intense concentration on mathematics or music. Moreover, such concentration is either a reflection of, or produced by, unusual ability in the specialized field.

While the first part of the book discusses mathematics in general terms, overlapping with the other two books under review, the last part is a collection of short biographies of many famous mathematicians from history. These biographies, which include some less well-known figures, are of interest in themselves, but they have been selected because of the light they may throw on the personality of mathematicians and the possible presence of Asperger's Syndrome. Any attempt to draw conclusions on the psychology of mathematicians from a small number of selected cases from famous figures of the past is fraught with difficulty.

But it is his experience as a teacher that gives the book some of its extraordinary salience and authority Good mathematics teaching should not banish ambiguity, but enable students to master it Everyone should read Byers His lively and important book establishes a framework and vocabulary to discuss doing, learning, and teaching mathematics, and why it matters.

Perfectly formalized ideas are dead, while ambiguous, paradoxical ideas are pregnant with possibilities and lead us in new directions: they guide us to new viewpoints, new truths Integrating his experience as a mathematician and as a Buddhist, Byers examines the validity of this assumption. Much of mathematical thought is based on intuition and is in fact outside the realm of black-and-white logic, he asserts. Byers introduces and defines terms such as mathematical ambiguity, contradiction, and paradox and demonstrates how creative ideas emerge out of them.

He gives as examples some of the seminal ideas that arose in this manner, such as the resolution of the most famous mathematical problem of all time, the Fermat conjecture. Next, he takes a philosophical look at mathematics, pondering the ambiguity that he believes lies at its heart. Finally, he asks whether the computer accurately models how math is performed. The author provides a concept-laden look at the human face of mathematics. What Byers's book reveals is that ambiguity is always present You can't quite say that nobody has said this before.

But nobody has said it before in this all-encompassing, coherent way, and in this readable, crystal clear style Or you assign to each boy his weight—that's a function, okay? You see, there's a psychological element to mathematics that most people aren't aware of. Have you ever heard of 'Occam's Razor'? It's named for the 13th century English philosopher William of Occam. In plain language, Occam's Razor means that you try to reduce your thinking to a few principles, the idea being that if you have your principles laid out clearly and you're logical, then if you reach a conclusion you don't want to reach, the only possible explanation is that there was something wrong with your original principles.

Mathematics supposedly follows Occam's Razor more closely than almost any other subject. There's nothing ad hoc in mathematics. The problem is figuring out where to start. You have to start with ideas that you can't really define, because everything is defined in terms of something else. One of the things you start with is function.

I've defined it—and you were satisfied with the definition I gave you, but you had only two minutes to think about it. The trouble is, I used the word 'rule,' and rule is not very precise. For instance, I could create the following function: It assigns to all women the number '1,' provided that there is life as we know it on Mars.

And it assigns them the number '0' if there is not life on Mars. That is a well-defined rule, but it's not very satisfying because we don't know if there is life on Mars. So when you start in mathematics, you either have to take 'function' or 'set' as the undefinable. The point I am trying to make is that for your undefinables you want something that is so logical, so intuitively appealing, that not many people are going to argue with it. Function and set seem to be surviving.

Everything else is based logically on these. I guess that's a sign that they system is healthy. He makes his living worrying about what mathematicians should be assuming, what our axioms ought to be. Many of his papers deal with questions like the following: Suppose we change our axioms to this, how will it change mathematics? It was an amazing piece of work, because if you believed it, it wiped out whole areas of philosophy. The response of the working philosophers at the time was, "This is terrible.

It puts us out of business. We have to ignore it. In mathematics, everybody has accepted the axiom system—with a few notable exceptions—everybody has accepted the way we do mathematics. That's not to say there aren't other psychological problems in mathematics. There is a famous list of questions posed in by Hilbert—there's Hilbert. In , he gave a speech to an international body of mathematicians in which he charted what he felt were the 20 or 25 most important problems that mathematics ought to consider in the 20th century.

People get promotions and tenure just for solving Hilbert problems. However, it turns out that some of the most intuitively appealing ones, the ones you most feel you would like to have answered, have no answer.

They can't be answered within the framework of mathematics as we know it. The axiom system that we work in—the Zermelo-Frankel set theory—people are not inclined to change. Your average working mathematician is not inclined to change it. Well, suppose you have a polynomial equation with integer coefficients. If you stare at the equation, is there some way to tell if it has integer solutions? That's a simple-minded version of a Hilbert question.

Ideally, what you would like to do is to take a polynomial—here's a polynomial. You set it equal to zero and solve for x, or more generally, it looks like this. The answer is, there is no way to do this. That answer would have been inconceivable in the 19th century. I don't mean, we can't do it or it's too hard or we don't know the right theory yet, I mean it can't be done. That's one of the psychological features of mathematics. Because the first one was a specific example of a polynomial and the second one represents any old polynomial.

I was just falling into the trap of being a mathematician then. I've mentioned some of them. Another one is that some proofs now are so complicated that no one can understand them. Everybody loves this problem.

Suppose you are Rand McNally and your job is to make a map, you don't want two adjacent countries to have the same color. Now, you are going to be printing maps from now to the end of time, and you don't know what kind of maps are going to come up, but you want to have the right number of colors in supply.

How many colors do you need? The professor couldn't answer it. People fiddled and fiddled with the question and after a while they proved that five colors would always do. They thought that four would do, but they couldn't prove it. One solution was published and believed for 20 years until somebody found a mistake. Finally about 10 years ago, two mathematicians at the University of Illinois, Appel and Haken, came up with a solution.

They proved that four colors will suffice—the University of Illinois is so proud of this that when you get a letter from their math department, the cancellation mark says 'Four colors suffice. Nobody can check their proof in the usual way. Previous research has found that these nonlinguistic areas are active when performing rudimentary arithmetic calculations and even simply seeing numbers on a page, suggesting a link between advanced and basic mathematical thinking.

In fact, co-author Stanislas Dehaene, director of the Cognitive Neuroimaging Unit and experimental psychologist, has studied how humans and even some animal species are born with an intuitive sense of numbers—of quantity and arithmetic manipulation—closely related to spatial representation.

This work raises the intriguing question of whether an innate capability to recognize different quantities—that two pieces of fruit are greater than one—is the biological foundation on which can be built the capacity to master group theory.

Ansari suggests that a training study, in which nonmathematicians are taught advanced mathematical concepts, could provide a better understanding of these connections and how they form. Moreover, achieving expertise in mathematics may affect neuronal circuitry in other ways. Although additional studies are needed to determine whether mathematicians actually do process faces differently, the researchers hope to gain further insight into the effects that expertise has on how the brain is organized.

Jordana Cepelewicz is a science writer based in New York City.






















Minus Related Pages. Those at high risk for developing TB disease include: People with HIV infection People who became infected with TB bacteria in the last 2 years Babies and young children People who inject illegal drugs People who are sick with other diseases that weaken the immune system Elderly people People who were not treated correctly for TB in the past If you have latent TB infection and you are in one of these high-risk groups, you should take medicine to keep from developing TB disease.

Learn about TB Risk Factors. Related Links. To receive email updates about this page, enter your email address: Email Address. What's this? Links with this icon indicate that you are leaving the CDC website. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.

To tell if someone has TB disease , other tests such as chest x-ray and a sample of sputum phlegm that is coughed up from deep in the lungs may be needed. If you have latent TB infection , you may need medicine to prevent getting TB disease later.

One or more drugs are used to treat latent TB infection. It is important that you take your medicine exactly as your doctor or health care worker tells you. TB disease can also be treated by taking medicine. If you have TB disease , it is very important that you finish the medicine, and take the drugs exactly as you are told.

If you stop taking the drugs too soon, you can become sick again. If you do not take the drugs correctly, the germs that are still alive may become difficult to treat with those drugs. If you have TB disease , it takes six months and possibly as long as one year to kill all the TB germs.

Remember, you will always have TB germs in your body unless you kill them with the right medicine. These people have conditions that make the body weaker, so it is difficult for them to fight TB germs. TB is caused when a person breathes in TB bacteria that are in the air.

So it is important that people with TB, who are not on effective treatment, do not release TB bacteria into the air when they cough. Cough etiquette means that if you have TB, or you might have TB, then when you cough you should cover your mouth and nose with a tissue. You should put your used tissue in a bin. If you don't have a tissue then you should cough or sneeze into your upper sleeve or elbow. You should not cough into your hands.

After you have coughed you should wash your hands. The BCG vaccine has been shown to provide children with excellent protection against the disseminated forms of TB.

However protection against pulmonary TB in adults is variable. Since most transmission originates from adult cases of pulmonary TB, the BCG vaccine is generally used to protect children, rather than to interrupt transmission among adults. The BCG vaccine will often result in the person vaccinated having a positive result to a TB skin test.

TB education is necessary for people with TB. People with TB need to know how to take their TB drugs properly. They also need to know how to make sure that they do not pass TB on to other people. But TB education is also necessary for the general public. The public needs to know basic information about TB for a number of reasons including reducing the stigma still associated with TB. TB drug treatment for the prevention of TB, also known as chemoprophylaxis, can reduce the risk of a first episode of active TB occurring in people with latent TB.

The surviving bacteria become resistant to that drug and often other antibiotics as well. Some TB bacteria have developed resistance to the most commonly used treatments, such as isoniazid and rifampin Rifadin, Rimactane. Some TB strains have also developed resistance to drugs less commonly used in TB treatment, such as the antibiotics known as fluoroquinolones, and injectable medications including amikacin and capreomycin Capastat.

These medications are often used to treat infections that are resistant to the more commonly used drugs. A healthy immune system often successfully fights TB bacteria.

However, several conditions and medications can weaken your immune system, including:. Your risk of getting tuberculosis is higher if you live in, emigrate from or travel to areas with high tuberculosis rates.

Areas include:. Without treatment, tuberculosis can be fatal. Untreated active disease typically affects your lungs, but it can affect other parts of your body, as well. If you test positive for latent TB infection, your doctor might advise you to take medications to reduce your risk of developing active tuberculosis. Only active TB is contagious.

If you have active TB , it generally takes a few weeks of treatment with TB medications before you're not contagious anymore. Follow these tips to help keep your friends and family from getting sick:.

This is the most important step you can take to protect yourself and others from tuberculosis. When you stop treatment early or skip doses, TB bacteria have a chance to develop mutations that allow them to survive the most potent TB drugs.